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当前位置: 首页 > 产品中心 > cellular_metabolism > 室内生物技术/LoTox™ 天然derp1(LTN-DP1-1)/1/LTN-DP1-1
商品详细室内生物技术/LoTox™ 天然derp1(LTN-DP1-1)/1/LTN-DP1-1
室内生物技术/LoTox™ 天然derp1(LTN-DP1-1)/1/LTN-DP1-1
室内生物技术/LoTox™ 天然derp1(LTN-DP1-1)/1/LTN-DP1-1
商品编号: LTN-DP1-1
品牌: inbio
市场价: ¥13700.00
美元价: 6850.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞代谢
公司分类: cellular_metabolism
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Allergen:nDer p 1 (Dermatophagoides pteronyssinus allergen 1), house dust mite
Unit:250µg
Source: D.pteronyssinus culture medium
Mol. Wt:24 kD
Purification:

From mite culture by multi-step chromatographic purification.Purity on silver stained SDS-PAGE >95%.

Concentration:See package insert.
Formulation:

Preservative and carrier-free in sterile, endotoxin-free,phosphate buffered saline, pH 7.4

Storage:Store at -20ºC
Notes:A LoTox™ product, Endotoxin ≤ 0.03EU/µg.Cysteine protease activity (see product insert) RFU @ 0.25µg/ml concentration.
PDB:1XKG, 2AS8, 3F5V X-ray crystal structures
Product Resources:

LoTox™ Natural Der p 1 Certificate of Analysis

Allergens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use.
References:
  1. Lombardero M, Heymann PW, Platts-Mills TAE, Fox JW, Chapman MD. Conformational stability of B cell epitopes on Group 1 and Group II Dermatophagoides spp. Allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol 1990;144:1353-1360.
  2. Hewitt CRA, Brown AP, Hart BJ, Pritchard DL. A major house dust mite allergen disrupts the Immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. J Exp Med 1995;182:1537-1544.
  3. Schultz O, Laing P, Sewell HF, Shakib F. Der p 1, a major allergen of the house dust mite, proteolytically cleaves the low affinity receptor for human IgE (CD23). Eur J Immunol 1995;25:3191-3194.
  4. King C, Brennan S, Thompson PJ, Stewart GA. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J Immunol 1998; 161:3645-3651.
  5. Gough L, Schultz O, Sewell HF, Shakib F. The cysteine protease activity of the major house dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody responses. J Exp Med 1999; 190:1897-1901.
  6. Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MD, Robinson C. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999; 104:123-133.
  7. Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A. Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol, 2009;386:520-530.
品牌介绍
indoor biotechnologies由前弗吉尼亚大学医学和微生物学教授,UVA哮喘和变态反应中心的成员Martin D. Chapman博士创立。Chapman博士是美国过敏,哮喘和免疫学研究院的院士,并曾担任美国国立卫生研究院,环境保护署,学术机构和《财富》 500强公司的顾问。室内生物技术专业生产抗过敏和哮喘的生物制剂。该公司是评估家庭,工作场所,学校和商业建筑中过敏原环境暴露的全球领导者。该公司生产用于过敏研究和诊断的高纯度过敏原,并在过敏原结构,功能和免疫识别方面的研究获得国际认可。室内生物技术的使命是改善过敏和哮喘患者的生活质量。